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    Prof. Frederick Chi-Ching Leung,

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    B.A., Ph.D. (Berkeley, California)

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    >> Click here to download the Full CV

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Professor

School of Biological Sciences
The University of Hong Kong
Telephone: (852) 2299 0825
Fax: (852) 2857 4672
E-mail: fcleung@hkucc.hku.hk

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   Research Interests:
  

   1. Molecular and Evolutionary Virology (SARS-CoV, IBDV, FMDV, PRRSV, PCV2 and Influenza )

   > Recombinant antiviral vaccines
   > Phylogenetics and epidemiology of RNA viruses
   > Viral receptors and tropism

   > Molecular biology of viral pathogenesis

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   2. Poultry Genomics and Endocrinology 

   > Molecular breeding of chicken

   > Molecular biology of chicken growth hormone genes

   > Characterization of repetitive sequences of Chicken genome 
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   3. Evolutionary Genomics 

   > Evolutionary role of CpG islands

   > Genome plasticity and  repetitive sequences 
  

   4. Traditional Chinese Medicine (TCM)

   > Application of TCMs in cancer therapy

   > Quality control of TCM by molecular biology
  

   5. Computer Applications in Molecular Biology

   > Manipulation and visualization of genome data

   > Analysis of DNA fingerprint data

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   Professorships


   01/07 - NOW: Professor, School of Biological Sciences, University of Hong Kong, Hong Kong

   09/94 - 12/06: Associate Professor, Department of Zoology, University of Hong Kong, Hong Kong
   01/00 - 02/06: Dean of Science, University of Hong Kong, Hong Kong

   10/89 - 10/94: Affiliate Faculty, Department of Fisheries, University of Washington, Seattle, WA
   08/89 - 10/94: Affiliate Associate Professor of Biochemistry, Department of Bacteriology and Biochemistry, University of Idaho,  Moscow, Idaho
   05/86 - 10/94: Adjunct Associate Professor, Department of Animal Sciences, Washington State University, Pullman, WA
   12/85 - 08/94: Senior Research Scientist, Cell Biology Section, Department of Biology and Chemistry, Pacific Northwest Laboratories, Richland, WA
   10/84 - 11/85: Research Fellow, Department of Animal Physiology, Basic Animal Science Division, Merck, Rahway, NJ
   09/82 - 11/85: Adjunct Appointment in Animal Science Department, Rutgers University, New Brunswick, NJ
   09/80 - 09/84: Senior Research Biochemist, Department of Animal Physiology, Basic Animal Science Division, Merck, NJ
   09/78 - 09/80: Postdoctoral Fellow in Dr. J. Meites's Lab, Michigan State University, East Lansing, MI
   07/79 - 09/79: Assistant Professor, Michigan State University, East Lansing, MI
   06/78 - 08/78: Assistant Professor, Department of Biological Science, California State University, Hayward, CA
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  Industrial Experiences

 
   09/80 - 11/85: Merck Sharp & Dohme Laboratories, USA
   12/85 - 08/94: Battelle-Pacific Northwest Laboratories, US Department of Energy National Laboratory, WA

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  Genbank Contributions

 
   Up to 26th April, 2006, Prof. Leung contributed 235 items to the Genbank, mainly on experimentally confirm Chicken cDNA sequences and RNA virus

   sequences including SARS, IBDV, PRRSV and FMDV.

  

  

  Publications

  

  Up to 15th May, 2010, Professor Leung has published 115 peer reviewed journal papers mainly related to endocrinology / virology /genomics.

 

Yuan J, Hon CC, Li Y, Wang D, Xu G, Zhang H, Zhou P, Poon LM, Lam TT, Leung FC, Shi Z 
  " Intra-species Diversity of SARS-Like Coronaviruses (CoVs) in Rhinolophus sinicus and Its Implications on the Origin of SARS-CoVs in human."
 J Gen Virol. 2010 Apr;91(Pt 4):1058-62. Epub 2009 Dec 16 [PUBMED] 

Li R , ..., Leung FC, ..., Wang J 
  "The sequence and de novo assembly of the giant panda genome."
  Nature. 2010 Jan 21;463(7279):311-7. Epub 2009 Dec 13. Erratum in: Nature. 2010 Feb 25;463(7284):1106 [PUBMED]

Wang Y, Li J, Yan Kwok AH, Ge W, Leung FC
  "A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and characterization of its tissue expression ."
  Gen Comp Endocrinol. 2010 Mar 1;166(1):200-10. Epub 2009 Oct 23 [PUBMED]

Yip CW, Hon CC, Shi M, Lam TT, Chow KY, Zeng F, Leung FC
  "Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses."
  Infect Genet Evol. 2009 Dec;9(6):1185-96. Epub 2009 Sep 30 [PUBMED]

Wang Y, Li J, Wang CY, Kwok AY, Zhang X, Leung FC
  "Characterization of the receptors for chicken GHRH and GHRH-related peptides: identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP)"
  Domest Anim Endocrinol. 2010 Jan;38(1):13-31. Epub 2009 Aug 31 [PUBMED]

 Lynch VJ, Tanzer A, Wang Y, Leung FC. , Gellersen B, Emera D, Wagner GP.
  "Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals."
  Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14928-33. Epub 2008 Sep 22.[PUBMED]

  Wang Y, Leung FC
  In silico prediction of two classes of honeybee genes with CpG deficiency or CpG enrichment and sorting according to gene ontology classes.
  J Mol Evol. 2009 Jun;68(6):700-5. Epub 2009 May 23 [PUBMED]

  Wang Y, Leung FC
  Discovery of a long inverted repeat in human POTE genes.
  Genomics. 2009 May 20 [PUBMED]

  Wang Y,  Leung FC
  Acquisition of inverted GSTM exons by an intron of primate GSTM5 gene.
  J Hum Genet. 2009;54(5):271-6. Epub 2009 Mar 20 [PUBMED]

  Wang Y,  Leung FC
  A study on genomic distribution and sequence features of human long inverted repeats reveals species-specific intronic inverted repeats.
  FEBS J. 2009 Apr;276(7):1986-98. Epub 2009 Feb 25 [PUBMED]

  Wang Y,  Leung FC
  Comparative genomic study reveals a transition from TA richness in invertebrates to GC richness in vertebrates at CpG flanking sites: an indication for context-dependent mutagenicity of methylated CpG sites.
  Genomics Proteomics Bioinformatics. 2008 Dec;6(3-4):144-54 [PUBMED]

  Wang J, Wang Y, Li X, Li J,  Leung FC
  Cloning, tissue distribution, and functional characterization of chicken glucagon receptor.
  Poult Sci. 2008 Dec;87(12):2678-88 [PUBMED]

  Hon CC, Lam TT, Yip CW, Wong RT, Shi M, Jiang J, Zeng F,  Leung FC
  Phylogenetic evidence for homologous recombination within the family Birnaviridae.
  J Gen Virol. 2008 Dec;89(Pt 12):3156-64 [PUBMED]

  Wang Y,  Leung FC
  GC content increased at CpG flanking positions of fish genes compared with sea squirt orthologs as a mechanism for reducing impact of DNA methylation..
  PLoS One. 2008;3(11):e3612. Epub 2008 Nov 13 [PUBMED]

  Lam TT, Hon CC, Pybus OG, Kosakovsky Pond SL, Wong RT, Yip CW, Zeng F,  Leung FC
  Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia..
  PLoS Pathog. 2008 Aug 22;4(8):e1000130 [PUBMED]

  Kwok AH, Wang Y, Wang CY,  Leung FC
  Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4)..
  Gen Comp Endocrinol. 2008 Jun;157(2):99-106. Epub 2008 Apr 6 [PUBMED]

  Hon CC, Lam TY, Shi ZL, Drummond AJ, Yip CW, Zeng F, Lam PY, Leung FC.

  Evidences of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus.
  J Virol. 2008 Feb;82(4):1819-26. Epub 2007 Dec 5; [PUBMED]

  Yeung YS, Yip CW, Hon CC, Chow KY, Ma IC, Zeng F, Leung FC
  Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: insights on viral regulation of apoptosis and proliferation.
  Virology. 2008 Feb 5;371(1):32-43. Epub 2007 Oct 24 [PUBMED]

  Lam TY, Hon CC, Wang Z, Hui RK, Zeng F,  Leung FC
  Evolutionary Analyses of European H1N2 swine infuenza A virus by placing timestamps on the multiple reassortment events.
  Virus Res . 2008 Feb;131(2):271-8. Epub 2007 Oct 23 [PUBMED]

  Wang Y., F. Zeng, C.C. Hon Y. Zhang, Leung FC.

  The mitochondrial genome of the Basidomycete fungus Pleurotus ostreatus (oyster mushroom). 
  FEMS Microbiology Letters. 2008 Mar;280(1):34-41. Epub 2008 Jan 31 [PUBMED]

  Lam TT, Hon CC, Lam PY, Yip CW, Zeng F, Leung FC
  Comments to the predecessor of human SARS coronavirus in 2003-2004 epidemic.
  Vet Microbiol. 2008 Jan 25;126(4):390-3. Epub 2007 Aug 17 [PUBMED]

  Hon CC, Lam TY, Shi ZL, Drummond AJ, Yip CW, Zeng F, Lam PY, Leung FC.

  Evidences of the Recombinant Origin of a Bat SARS-like Coronavirus and its Implications on the Direct Ancestor of SARS Coronavirus.
  J Virol. 2007 Dec 5; [PUBMED]

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  Wang CY, Wang Y, Kwok AH,  Leung FC
  Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand
  receptor interaction.
  J Endocrinol. 2007 Dec;195(3):525-36[PUBMED]

  Yeung YS, Yip CW, Hon CC, Chow KY, Ma IC, Zeng F,  Leung FC.
  Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation.
   Virology. 2008 Feb 5;371(1):32-43. [PUBMED]

  Lam TY, Hon CC, Wang Z, Hui RK, Zeng F,  Leung FC.
  Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events.
  Virus Res. 2007 Oct 11[PUBMED]

  Lam TT, Hon CC, Lam PY, Yip CW, Zeng F,  Leung FC.
  Comments to the predecessor of human SARS coronavirus in 2003-2004 epidemic.

  Vet Microbiol. 2008 Jan 25;126(4):390-3.[PUBMED]

  Wong RT, Hon CC, Zeng F,  Leung FC.
  Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA
  microarrays.
  J Gen Virol. 2007 Jun;88(Pt 6):1785-96.[PUBMED]

  Ma CM, Hon CC, Lam TY, Li VY, Wong CK, de Oliveira T, Leung FC.
  Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China.
  J Gen Virol. 2007 Jun;88(Pt 6):1733-7.[PUBMED]

  Wang Y, Li J, Ying Wang C, Yan Kwok AH,  Leung FC.
  Epidermal growth factor (EGF) receptor ligands in the chicken ovary: I. Evidence for heparin-binding EGF-like growth factor (HB-EGF) as a potential

  oocyte-derived signal to control granulosa cell proliferation and HB-EGF and kit ligand expression.
  Endocrinology. 2007 Jul;148(7):3426-40. [PUBMED]

  Wang CY,  Leung FC.
  Description of a synteny on the chicken chromosome zp23-22.
  Poult Sci. 2007 Mar;86(3):453-9.[PUBMED]

  Leung FC.
  Comments on the Fujian-like strain of avian influenza H5N1.
  Poult Sci. 2007 Mar;86(3):435-6;[PUBMED]

  Wang Y, Li J, Wang CY, Kwok AH, Leung FC.
  Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor: evidence for a separate gene encoding GHRH in

  submammalian vertebrates.
  Endocrinology. 2007 May;148(5):2405-16.[PUBMED]

  Kwok AH, Wang Y, Wang CY,  Leung FC.
  Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extrapituitary tissues.
  Poult Sci. 2007 Feb;86(2):423-30.[PUBMED]

  Li J, Wang X, Leung FC.
  The intragenomic polymorphism of a partially inverted repeat (PIR) in Gallus gallus domesticus, potential role of inverted repeats in satellite DNAs

  evolution.
  Gene. 2007 Jan 31;387(1-2):118-25.[PUBMED]

  Yip CW, Hon CC, Zeng F, Chow KY, Chan KH, Peiris JS,
Leung FC.
  Naturally occurring anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant nucleocapsid
  protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory syndrome.
  Clin Vaccine Immunol. 2007 Jan;14(1):99-101. [PUBMED]

  Wang Y, Wang Z, Li J, Wang Y,
Leung FC.
  Database for chicken full-length cDNAs.
  Physiol Genomics. 2007 Jan 17;28(2):141-5.[PUBMED]

  Zeng F, Hon CC, Yip CW, Law KM, Yeung YS, Chan KH, Malik Peiris JS,
Leung FC.
  Quantitative comparison of the efficiency of antibodies against S1 and S2 subunit of SARS coronavirus spike protein in virus neutralization and blocking of
  receptor binding: implications for the functional roles of S2 subunit.
  FEBS Lett. 2006 Oct 16;580(24):5612-20.[PUBMED]


  Yip CW, Yeung YS, Ma CM, Lam PY, Hon CC, Zeng F,
Leung FC.
  Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Vero cells.
  Virus Res. 2007 Jan;123(1):50-6. [PUBMED]

  Hon CC, Lam TY, Drummond A, Rambaut A, Lee YF, Yip CW, Zeng F, Lam PY, Ng PT,
Leung FC. .
  Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment

  B.
  J Virol. 2006 Sep;80(17):8503-9.[PUBMED]

  Lau JS, Yip CW, Law KM,
Leung FC.
  Cloning and characterization of chicken growth hormone binding protein (cGHBP).
  Domest Anim Endocrinol. 2007 Jul;33(1):107-21.[PUBMED]
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  Jinding C, Mingqiu Z, Hui KH, Leung FC.
  Molecular Characterization of Foot-and-mouth Disease Virus in Hong Kong During 2001-2002.
  Virus Genes. 2006 Apr;32(2):139-43. [PUBMED]

  Wang CY, Wang Y, Li J, Leung FC..
  Expression profiles of growth hormone-releasing hormone and growth hormone-releasing hormone receptor during chicken
embryonic pituitary

  development.
  Poult Sci. 2006 Mar;85(3):569-76. [PUBMED]

  Li J, Leung FC..
  A CR1 element is embedded in a novel tandem repeat (HinfI repeat) within the chicken genome.
  Genome. 2006 Feb;49(2):97-103. [PUBMED]

  Wang Y, Leung FC..
  Long inverted repeats in eukaryotic genomes: recombinogenic motifs determine genomic plasticity.
  FEBS Lett. 2006 Feb 20;580(5):1277-84. [PUBMED]

  Chow KY, Yeung YS, Hon CC, Zeng F, Law KM, Leung FC..
  Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.
  FEBS Lett. 2005 Dec 19;579(30):6699-704. [PUBMED]

  Zeng F, Hon CC, Sit WH, Chow KY, Hui RK, Law IK, Ng VW, Yang XT, Leung FC, Wan JM.
  Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray.
  Int J Oncol. 2005 Aug;27(2):513-23. [PUBMED]

  Liang Y, Cui J, Yang G, Leung FC, Zhang X.
  Polymorphisms of 5' flanking region of chicken prolactin gene.
  Domest Anim Endocrinol. 2006 Jan;30(1):1-16. [PUBMED]

  Qin J, Leung FC, Fung Y, Zhu D, Lin B.
  Rapid authentication of ginseng species using microchip electrophoresis with laser-induced fluorescence detection.
  Anal Bioanal Chem. 2005 Feb;381(4):812-9. [PUBMED]

  Chow KY, Hon CC, Hui RK, Wong RT, Yip CW, Zeng F, Leung FC.
  Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
  Genomics Proteomics Bioinformatics. 2003 Nov;1(4):247-62. [PUBMED]

  Wang Y, Rocha EP, Leung FC, Danchin A.
  Cytosine methylation is not the major factor inducing CpG dinucleotide deficiency in bacterial genomes.
  J Mol Evol. 2004 Jun;58(6):692-700. [PUBMED]

   Wang Y, Leung FC.
   DNA structure constraint is probably a fundamental factor inducing CpG deficiency in bacteria.
   Bioinformatics. 2004 Dec 12;20(18):3336-45. [PUBMED]

   Ip SC, Lau JS, Au WL, Leung FC.
   Characterization of the 5'-flanking transcriptional regulatory region of chicken growth hormone gene.
   Exp Biol Med (Maywood). 2004 Jul;229(7):640-9. [PUBMED]

   Yip CW, Hon CC, Zeng F, Chow KY, Leung FC.
    Prevalence of non-pneumonic infections with SARS-correlated virus.
    Lancet. 2004 May 29;363(9423):1825. [PUBMED]

    Hui RK, Zeng F, Chan CM, Yuen KY, Peiris JS, Leung FC.
    Reverse transcriptase PCR diagnostic assay for the coronavirus associated with severe acute respiratory syndrome.
    J Clin Microbiol. 2004 May;42(5):1994-9. [PUBMED]

    Zeng F, Chow KY, Hon CC, Law KM, Yip CW, Chan KH, Peiris JS, Leung FC.
    Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments.
    Biochem Biophys Res Commun. 2004 Mar 19;315(4):1134-9. [PUBMED]

    Wang Y, Leung FC.
    An evaluation of new criteria for CpG islands in the human genome as gene markers.
    Bioinformatics. 2004 May 1;20(7):1170-7. [PUBMED]

    Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY,

    Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC.
    Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome.
    Lancet. 2004 Jan 10;363(9403):99-104. [PUBMED]

   Zeng F, Chow KY, Leung FC.
   Estimated timing of the last common ancestor of the SARS coronavirus.
   N Engl J Med. 2003 Dec 18;349(25):2469-70. [PUBMED]

   Hon CC, Chow YC, Zeng FY, Leung FC.
   Genetic authentication of ginseng and other traditional Chinese medicine.
   Acta Pharmacol Sin. 2003 Sep;24(9):841-6. [PUBMED]

   Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY,
   Wang CY, Wang PY, Guan Y, Zheng B, Poon LL, Chan KH, Yuen KY, Peiris JS, Leung FC.
   The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39).
   Exp Biol Med (Maywood). 2003 Jul;228(7):866-73. [PUBMED]

   Leung FC.
   Hong Kong SARS sequence.
   Science. 2003 Jul 18;301(5631):309-10. [PUBMED]

   Zhang X, Leung FC, Chan DK, Yang G, Wu C.
   Genetic diversity of Chinese native chicken breeds based on protein polymorphism, randomly amplified polymorphic DNA, and microsatellite

   polymorphism.
   Poult Sci. 2002 Oct;81(10):1463-72. [PUBMED]

   Nie Q, Ip SC, Zhang X, Leung FC, Yang G.
   New variations in intron 4 of growth hormone gene in Chinese native chickens.
   J Hered. 2002 Jul-Aug;93(4):277-9. [PUBMED]

   Zhang X, Leung FC, Chan DK, Chen Y, Wu C.
   Comparative analysis of allozyme, random amplified polymorphic DNA,

   and  microsatellite polymorphism on Chinese native chickens.
   Poult Sci. 2002 Aug;81(8):1093-8. [PUBMED]

   Au WL, Leung FC.
   Rapid communication: complete nucleotide sequence of the chicken prolactin gene.
   J Anim Sci. 2002 May;80(5):1381. [PUBMED]

   Wang X, Li J, Leung FC.
   Partially inverted tandem repeat isolated from pericentric region of chicken chromosome 8.
   Chromosome Res. 2002;10(1):73-82. [PUBMED]
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   Ho IS, Leung FC.
   Isolation and characterization of repetitive DNA sequences from Panax ginseng.
   Mol Genet Genomics. 2002 Feb;266(6):951-61.  [PUBMED]

   Ip SC, Zhang X, Leung FC.
   Genomic growth hormone gene polymorphisms in native Chinese chickens.
   Exp Biol Med (Maywood). 2001 May;226(5):458-62. [PUBMED]
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   Wang Y, Guo Y, Shen X, Leung FC.
   DNA polymorphism in the genomes of different Escherichia coli strains
   Wei Sheng Wu Xue Bao. 1997 Dec;37(6):455-62. Chinese. [PUBMED]

   Leung FC.
   New applications of low-C0tDNA as a DNA fingerprint probe.
   Electrophoresis. 1999 Jun;20(8):1762-7. [PUBMED]

   Archer ES, Leung FC.
   Computer program for automatically calculating similarity indexes from DNA fingerprints.
   Biotechniques. 1998 Aug;25(2):252-4. [PUBMED]

   Cao YC, Yeung WS, Law M, Bi YZ, Leung FC, Lim BL.
   Molecular characterization of seven Chinese isolates of infectious bursal disease virus: classical, very virulent, and variant strains.
   Avian Dis. 1998 Apr-Jun;42(2):340-51. [PUBMED]

   Archer ES, Yee LW, Leung FC.
   Visual Genome Explorer: a comparative visual interface to genome data.
   Biotechniques. 1997 Jun;22(6):1164-5. [PUBMED]

   Scott DA, Welt M, Leung FC.
   A computer program to aid in calculating similarity indexes from DNA fingerprints.
   Biotechniques. 1993 Jun;14(6):980-3. [PUBMED]

   Leung FC.
   Circadian rhythms of melatonin release from chicken pineal in vitro: modified melatonin radioimmunoassay.
   Proc Soc Exp Biol Med. 1991 Dec;198(3):826-32. [PUBMED]

   Leung FC, Bohn LR, Dagle GE.
   Elevated epidermal growth factor receptor binding in plutonium-induced lung tumors from dogs.
   Proc Soc Exp Biol Med. 1991 Apr;196(4):385-9. [PUBMED]

   Leung FC.
   Growth factor and growth factor receptor in radiation carcinogenesis.
   Radiat Environ Biophys. 1991;30(3):191-4. [PUBMED]

   Leung FC, Bowen DL, Chandler DP.
   Construction of a biologically active recombinant DNA plasmid containing a mouse metallothionein promoter and genomic bovine growth hormone gene.
   Nucleic Acids Res. 1990 Aug 25;18(16):4942. [PUBMED]

   Thommes RC, Umporowicz DM, Leung FC, Woods JE.
   Ontogenesis of immunocytochemically demonstrable somatotrophs in the adenohypophyseal pars distalis of the developing chick embryo.
   Gen Comp Endocrinol. 1987 Sep;67(3):390-8. [PUBMED]

   Leung FC, Styles WJ, Rosenblum CI, Lilburn MS, Marsh JA.
   Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens.
   Proc Soc Exp Biol Med. 1987 Feb;184(2):234-8. [PUBMED]

   Taylor JE, Ball CA, Leung FC.
   Interaction of human pancreatic growth hormone-releasing factor, thyrotropin-releasing hormone, and somatostatin on growth hormone release in

   chickens.
   Proc Soc Exp Biol Med. 1986 Dec;183(3):363-7. [PUBMED]

   Leung FC, Jones B, Steelman SL, Rosenblum CI, Kopchick JJ.
   Purification and physiochemical properties of a recombinant bovine growth hormone produced by cultured murine fibroblasts.
   Endocrinology. 1986 Oct;119(4):1489-96. [PUBMED]

   Lilburn MS, Leung FC, Ngiam-Rilling K, Smith JH.
   The relationship between age and genotype and circulating concentrations of triiodothyronine (T3), thyroxine (T4), and growth hormone in commercial

   meat strain chickens.
   Proc Soc Exp Biol Med. 1986 Jul;182(3):336-43. [PUBMED]

   Lilburn MS, Ngiam-Rilling K, Leung FC, Smith JH.
   The relationship between age and genotype and the growth of commercial meat strain chickens.
   Proc Soc Exp Biol Med. 1986 Jul;182(3):328-35. [PUBMED]

   Leung FC, Taylor JE, Wien S, Van Iderstine A.
   Purified chicken growth hormone (GH) and a human pancreatic GH-releasing hormone increase body weight gain in chickens.
   Endocrinology. 1986 May;118(5):1961-5. [PUBMED]

   Leung FC.
   Avian hormones.
   Basic Life Sci. 1986;37:113-25. [PUBMED]

   Kopchick JJ, Pasleau F, Leung FC.
   Expression of the bovine growth hormone gene in cultured rodent cells.
   Basic Life Sci. 1986;37:19-37. [PUBMED]

   Leung FC, Taylor JE, Van Iderstine A.
   Effects of dietary thyroid hormones on growth, plasma T3 and T4, and growth hormone in normal and hypothyroid chickens.
   Gen Comp Endocrinol. 1985 Jul;59(1):91-9. [PUBMED]

   Burch WM, Corda G, Kopchick JJ, Leung FC.
   Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro.
   J Clin Endocrinol Metab. 1985 Apr;60(4):747-50. [PUBMED]

   Kopchick JJ, Malavarca RH, Livelli TJ, Leung FC.
   Use of avian retroviral-bovine growth hormone DNA recombinants to direct expression of biologically active growth hormone by cultured fibroblasts.
   DNA. 1985 Feb;4(1):23-31. [PUBMED]
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   Leung FC, Taylor JE, Steelman SL, Bennett CD, Rodkey JA, Long RA, Serio R, Weppelman RM, Olson G.
   Purification and properties of chicken growth hormone and the development of a homologous radioimmunoassay.
   Gen Comp Endocrinol. 1984 Dec;56(3):389-400. [PUBMED]

   Leung FC, Taylor JE, Van Iderstine A.
   Effects of dietary thyroid hormones on growth and serum T3, T4, and growth hormone in sex-linked dwarf chickens.
   Proc Soc Exp Biol Med. 1984 Oct;177(1):77-81. [PUBMED]

   Leung FC, Taylor JE, van Iderstine A.
   Thyrotropin-releasing hormone stimulates body weight gain and increases thyroid hormones and growth hormone in plasma of 

   cockerels.
   Endocrinology. 1984 Aug;115(2):736-40. [PUBMED]

   Leung FC, Taylor JE.
   In vivo and in vitro stimulation of growth hormone release in chickens by synthetic human pancreatic growth hormone releasing factor (hpGRFs).
   Endocrinology. 1983 Nov;113(5):1913-5. [PUBMED]

   Leung FC, Alysworth CF, Meites J.
   Counteraction of underfeeding-induced inhibition of mammary tumor growth in rats by prolactin and estrogen administration.
   Proc Soc Exp Biol Med. 1983 May;173(1):159-63. [PUBMED]

   Van Vugt DA, Aylsworth CF, Sylvester PW, Leung FC, Meites J.
   Evidence for hypothalamic noradrenergic involvement in naloxone-induced stimulation of luteinizing hormone release.
   Neuroendocrinology. 1981 Nov;33(5):261-4. [PUBMED]

   Leung FC, Chen HT, Verkaik SJ, Steger RW, Peluso JJ, Campbell GA, Meites J.
   Mechanism(s) by which adrenalectomy and corticosterone influence prolactin release in the rat.
   J Endocrinol. 1980 Oct;87(1):131-40. [PUBMED]

   Leung FC.
   Relationship between radioreceptor assay and radioimmunoassay estimates of prolactin in rat pituitary tissue, incubation
medium, and serum: effects of

   dialysis on measurements of the hormone.
   Endocrinology. 1980 Jan;106(1):61-7. [PUBMED]

   Leung FC, Russell SM, Nicoll CS.
   Relationship between bioassay and radioimmunoassay estimates of prolactin in rat serum.
   Endocrinology. 1978 Nov;103(5):1619-28. [PUBMED]

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